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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
13.33
Human Site:
S427
Identified Species:
20.95
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S427
S
S
L
L
D
T
S
S
V
L
V
T
Q
E
P
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S427
S
S
L
L
D
T
S
S
V
L
V
T
Q
E
P
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S427
A
S
L
L
D
T
S
S
V
L
V
T
Q
E
P
Dog
Lupus familis
XP_536323
888
97475
V427
S
S
L
L
D
T
S
V
E
L
E
T
Q
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
A427
S
V
A
S
P
P
S
A
L
G
T
Q
E
P
G
Rat
Rattus norvegicus
P51639
887
96670
A427
S
A
A
S
P
P
L
A
L
G
A
Q
E
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
S414
C
N
P
E
E
T
S
S
V
L
N
K
K
E
E
Frog
Xenopus laevis
P20715
883
96702
P424
S
S
P
L
E
L
S
P
E
D
K
N
T
M
F
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
H435
D
E
T
Q
E
N
T
H
V
S
E
P
V
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
Q468
I
K
P
P
R
P
V
Q
E
C
L
D
I
L
N
Honey Bee
Apis mellifera
XP_623118
908
99432
S438
S
N
D
K
N
L
F
S
Q
I
P
R
S
V
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
E440
S
G
S
E
D
E
E
E
E
V
I
K
E
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
L171
G
K
V
P
S
Y
A
L
E
A
R
L
G
D
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
I184
K
S
V
I
D
G
V
I
P
S
Y
S
L
E
S
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
E584
S
G
P
S
S
S
S
E
E
D
D
S
R
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
80
N.A.
13.3
6.6
N.A.
N.A.
40
26.6
6.6
N.A.
0
13.3
N.A.
20
P-Site Similarity:
100
100
100
80
N.A.
33.3
33.3
N.A.
N.A.
60
33.3
20
N.A.
6.6
33.3
N.A.
40
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
14
0
0
0
7
14
0
7
7
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% C
% Asp:
7
0
7
0
40
0
0
0
0
14
7
7
0
14
0
% D
% Glu:
0
7
0
14
20
7
7
14
40
0
14
0
20
47
20
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% F
% Gly:
7
14
0
0
0
7
0
0
0
14
0
0
7
0
14
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
0
0
0
7
0
7
7
0
7
0
7
% I
% Lys:
7
14
0
7
0
0
0
0
0
0
7
14
7
0
0
% K
% Leu:
0
0
27
34
0
14
7
7
14
34
7
7
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% M
% Asn:
0
14
0
0
7
7
0
0
0
0
7
7
0
0
7
% N
% Pro:
0
0
27
14
14
20
0
7
7
0
7
7
0
14
27
% P
% Gln:
0
0
0
7
0
0
0
7
7
0
0
14
27
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
7
7
7
0
0
% R
% Ser:
60
40
7
20
14
7
54
34
0
14
0
14
7
0
14
% S
% Thr:
0
0
7
0
0
34
7
0
0
0
7
27
7
0
0
% T
% Val:
0
7
14
0
0
0
14
7
34
7
20
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _